Skip to content
Can Vitamin B6 Help With Anxiety

Can Vitamin B6 Help With Anxiety?


Have you ever pondered over the possibility that selective B vitamins might have the potential to alleviate anxiety?

It's commonly known that most B-complex supplements available in the market are promoted predominantly for their role in boosting energy levels.

However, what might surprise you is each B vitamin's distinctive role when we dissect the complex, shedding light on its unique influence over various bodily functions.

In the grand tapestry of nutrition, B vitamins play pioneering roles. Each member of the B vitamin family performs specific tasks, uniquely contributing to the body's overall well-being.

We unearth the individual B vitamins' specific roles by diving into the vitamin B complex's well. Their responsibilities range from aiding in cell metabolism to keeping our skin healthy.

They are crucial for brain function and are also pivotal in the production of red blood cells.

The marvel of B vitamins extends beyond the obvious. In the context of mental health, particularly anxiety, it's fascinating to observe their potential beneficial role in improving cognitive function.

The complexity and depth of the impacts highlight the importance of considering individual consumption of these critical nutrients, as they may provide relief from anxiety symptoms for some people.

A better understanding of individual B vitamins' roles could revolutionize perceptions about their utility beyond merely giving energy. Their influence on the body extends beyond what is typically marketed, proving the adage true: there is more than meets the eye.

What are B Vitamins?

B vitamins, a class of water-soluble nutrients, are vital in maintaining overall health and well-being. These essential nutrients participate in a wide range of biological processes in the body, from energy production and cellular health to brain function and cardiovascular wellness.

In this section, we will delve into the importance of each B vitamin variant to provide a comprehensive understanding of their unique contributions to our body's daily operations and optimal functioning.

B1 (Thiamine)

Thiamine plays a pivotal role in our body's metabolic processes. It facilitates the conversion of food into usable energy and plays a critical role in supporting healthy nerve function. Thiamine is instrumental in metabolizing carbohydrates, often considered the body's preferred energy source.

B2 (Riboflavin)

Riboflavin, another integral nutrient, is predominantly involved in energy production. Additionally, it contributes significantly to the health of our skin and eyes. One of its less evident yet essential functions is to help the body metabolize other important bio factors – such as vitamin B6 and folate – into their respective active forms.

B3 (Niacin)

Niacin, too, plays a substantial role in converting food into energy. Beyond energy production, this vital nutrient works to repair damaged DNA, maintain skin health and manage cholesterol levels - contributing positively to cardiovascular health.

B5 (Pantothenic Acid)

Pantothenic acid, or vitamin B5, is indispensable as a chemical building block for synthesizing numerous vital substances. These include fatty acids, amino acids, and a host of hormones and neurotransmitters regulating bodily functions.

B6 (Pyridoxine)

Pyridoxine, another fundamental B vitamin, participates in over 100 enzymatic reactions within our body, including the metabolism of amino acids - the building blocks of proteins. Further, it assists in producing neurotransmitters, which serve as chemical messengers in our nervous system.

B7 (Biotin)

Biotin is spotlighted often for its role in maintaining healthy hair, skin, and nails. Yet, what often goes unmentioned is its importance in our metabolic processes, helping metabolize fatty acids, amino acids, and glucose into usable forms of energy.

B9 (Folate)

Folate commands a critical position, especially in the context of pregnancy. It is essential for DNA synthesis, cell division, and the formation of red blood cells. More critically, a sufficient intake of folate during pregnancy helps to prevent neural tube defects in the developing fetus.

B12 (Cobalamin)

Cobalamin, or B12, is renowned for its significant involvement in the production of red blood cells, DNA synthesis, and nerve function. It maintains the health of nerve cells, contributes to the metabolism of fatty acids, and aids other B vitamins in their various functions.

The Role of Vitamin B6

Among the entire spectrum of B vitamins, vitamin B6, scientifically termed pyridoxine, has been consistently linked in numerous studies to alleviate and manage anxiety symptoms.

This vital micronutrient profoundly impacts brain health due to its active role in neurotransmitter synthesis.

Primarily, pyridoxine fuels the production of neurotransmitters such as serotonin and gamma-aminobutyric acid (GABA). Serotonin, often called the "feel-good" hormone, significantly stabilizes moods, fosters a sense of well-being, and induces happiness.

On the other hand, GABA operates as an inhibitory neurotransmitter, reducing neuronal excitability and exerting calming effects on the mind.

By boosting the levels of these critical neurotransmitters, vitamin B6 contributes to enhanced mood regulation, stress reduction, and overall emotional well-being. Therefore, consistent and adequate intake of B6 could promote sound mental health and serve as a supportive strategy in managing anxiety symptoms.

Here's how vitamin B6 may be linked to alleviating anxiety:

Serotonin Production

Commonly dubbed the "feel-good" neurotransmitter, serotonin plays a central role in managing emotions, reducing anxiety, and moderating sleep cycles. Vitamin B6 is an invaluable coenzyme in transforming from tryptophan—an essential amino acid—to serotonin.

Ensuring a sufficient intake of vitamin B6 can help sustain well-balanced serotonin levels, leading to a positive influence on one's mood and a potential decrease in anxiety-related symptoms, especially in older adults who are at high risk for B vitamin deficiency.

Additionally, vitamin B6 also plays a role in maintaining normal levels of homocysteine, an amino acid in the blood. This further contributes to overall well-being, cognitive development, and immune function 

GABA Synthesis

Gamma-aminobutyric acid (GABA) is recognized as an inhibitory neurotransmitter that exerts calming effects on the brain, acting as the brain's natural 'brake pedal' against neuronal excitation.

Vitamin B6 aids in the enzymatic conversion of glutamate—an excitatory neurotransmitter—into GABA. As such, maintaining appropriate levels of GABA, assisted by sufficient vitamin B6, can contribute to managing anxiety more effectively and promoting a relaxed mindset.

Supporting Magnesium Absorption

In addition to neurotransmitter synthesis, vitamin B6 serves another critical function related to anxiety management; it enhances the absorption and utility of magnesium in our bodies.

This mineral plays numerous roles—a key one being its calming impact on the nervous system and adrenal glands, particularly under acute stress conditions.

Vitamin B6 indirectly contributes to stress reduction and anxiety relief by facilitating the body's use of magnesium, further highlighting its importance in mental health.

Evidence linking Vitamin B6 to Alleviating Anxiety

Emerging research underscores the potential anxiety-reducing effects of vitamin B6 when administered as a stand-alone supplement in young adults.

In one study, 478 young adults were randomly assigned to receive either vitamin B6 or B12. The data collected showed that young adults supplemented with vitamin B6, such as tuna, demonstrated significant mood improvements compared to the B12 group. The effects were attributed to the elevated levels of GABA – a neurotransmitter that supports mood regulation and anxiety control – observed in young adults who received the B6 supplement.

This study aligns with the evidence linking Vitamin B6 to alleviating anxiety and highlights the advantage of nutrition-based interventions, which produce far fewer unpleasant side effects than drugs, as mentioned in a study published in Human Psychopharmacology: Clinical and Experimental. Taking high doses of vitamin B6 tablets has been shown to reduce feelings of anxiety and depression, according to the results of a study conducted by University of Reading investigators. The study results, published in Human Psychopharmacology: Clinical and Experimental, showed evidence to support the use of supplements to modify levels of activity in the brain to prevent or treat mood disorders.

Vitamin B6 has been used to treat symptoms of PMS, such as anxiety, depression, irritability, and vomiting, due to its role in creating neurotransmitters that regulate mood. Vitamin B6 has also been used for decades to treat nausea and vomiting during pregnancy, making it a versatile nutrient for various conditions. Randomized trials have shown that a combination of vitamin B6 and doxylamine (an antihistamine) is associated with a 70% reduction in nausea and vomiting in pregnant individuals and lower hospitalization rates for this problem [25,29].

Another study further reinforces the potential of vitamin B6 in anxiety management. Participants subjected to vitamin B6 supplementation also reported progress in their mood and anxiety levels, echoing the findings of the first investigation. A close examination of the study and its implications can be found here.

Interestingly, a third study extends the dialogue to the combined effects of vitamin B6 and magnesium in managing stress and anxiety-related symptoms in healthy individuals. Participants who took both of these supplements concurrently reported considerable alleviation of stress and anxiety-related symptoms in their self-assessments.

The synergistic response of vitamin B6 and magnesium highlights an avenue for comprehensive anxiety management that warrants further exploration for healthy individuals.

The Multifaceted Benefits of B6

Amino Acid Metabolism

Vitamin B6 plays a pivotal role in the metabolism of amino acids - the basic units of proteins. It orchestrates the interconversion between different amino acids, which is vital for creating diverse proteins that assist in the body's structural maintenance, functionality, and repair.

Neurotransmitter Synthesis

As a crucial cofactor, Vitamin B6 facilitates the synthesis of critical neurotransmitters, encompassing serotonin, dopamine, and gamma-aminobutyric acid (GABA). These biochemical signalers are indispensable for regulating moods, optimizing sleep, and promoting overall cognitive health.

Formation of Hemoglobin

A critical function of Vitamin B6 lies in its involvement in hemoglobin synthesis. Hemoglobin, the oxygen-carrying protein in red blood cells, relies on adequate B6 levels for its creation, enabling optimal oxygen transportation throughout the body.

Immune Enhancement

Known for bolstering the immune system, vitamin B6 propels the production and operation of white blood cells, the body's frontline defense against infections. Hence, it's a key ally for maintaining robust immunity.

Glycogen Breakdown

Vitamin B6 plays an instrumental role in glycogenolysis, converting glycogen - the stored glucose in muscle and liver tissues - into a readily available energy source during periods of need.

Hormone Regulation

Embracing a regulatory role, vitamin B6 affects the balance of various hormones. It contributes to the homeostasis of hormones involved in sleep-wake cycles and the regularity of female menstrual cycles.

Skin Health Support

The health of your skin, hair, and nails receives an assist from vitamin B6. It aids in synthesizing collagen, a structural protein in the skin's connective tissue, contributing to maintaining a healthy complexion and overall skin health.

Even though our range of testing doesn't encompass vitamins, we conduct extensive mineral analysis.

For individuals battling chronic magnesium deficiency or grappling with mental health issues such as anxiety or depression, a suitable supplement may be the answer.

Our specially curated product, "Upgraded Cramp Relief," is a compelling magnesium and vitamin B6 blend. Initially designed to cater to ailments such as menstrual pain and leg cramps, user feedback and scientific indicators have revealed further advantages.

Notably, this dual-component supplement not only soothes physical discomfort but has also demonstrated effectiveness in mood elevation and enhanced magnesium absorption.

Thus, it simultaneously offers a holistic approach to managing cramps and psychological well-being.


In conclusion, B vitamins, specifically B6, exhibit substantial potential in managing and mitigating anxiety symptoms. Pyridoxine, or vitamin B6, regulates neurotransmitters responsible for mood regulation and stress response.

It also aids in utilizing and absorbing magnesium, an essential element for the nervous and adrenal glandular system during times of stress.

Several scientific studies corroborate the anxiety-reducing benefits of B6, whether taken in isolation or combination with magnesium.

These findings underline the importance of assessing one's nutritional needs accurately. Those struggling with chronic anxiety, depression, or even magnesium deficiency may find relief by incorporating supplements such as our Upgraded Cramp relief, which contains both magnesium and B6.

Curious about your magnesium status? Feel free to explore our HTMA testing by clicking the link provided.

Always remember the path to improved health often starts with understanding the necessary nutrients that support bodily functions.

If you want to understand your magnesium levels, we invite you to utilize our Hair Tissue Mineral Analysis (HTMA) services.

This analysis can provide insightful details about your body's magnesium status, serving as a proactive step towards better health.


Older Post
Newer Post
Close (esc)


Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.

Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.


Shopping Cart