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Got Histamine Issues

Got Histamine issues? It Might Be Copper Dysregulation!

Got Histamine issues? It Might Be Copper Dysregulation!

Do you find yourself burdened with numerous allergies throughout the year, making it challenging to maintain a comfortable demeanor? It's possible that you've begun experiencing sudden reactions to various foods, such as bone broth, collagen, cheeses, yogurts, or even strawberries. You might be wondering, what could be the underlying cause of these adverse reactions? It turns out, the culprit is often histamines.

Understanding Histamines

Histamines are proteins predominantly regulated by our immune system. They are produced as a response mechanism to eject irritants from our bodies, effectively causing allergic reactions. Consider, for instance, when pollen enters your mouth, your body's histamine response provokes you to sneeze, thus expelling the unwelcome particles. However, histamine responses vary and manifest themselves through different symptoms including swelling, rashes, watery eyes, and headaches. In severe cases where histamines are at excessively high levels, they may even trigger vomiting.

Apart from their role in allergic reactions, histamines are crucial in various other physiological processes. They help regulate gastric acidity, aiding in digestion. They also stimulate the brain by interacting with hormones and neurotransmitters. In females, histamines play a vital role in the reproductive cycle, providing insight into why women with impaired histamine clearance may experience severe premenstrual syndrome (PMS) symptoms. Thus, maintaining histamine regulation is integral not only for managing allergies but also for overall health and well-being.


Histamines and their role in the Immune System

Histamines are produced by immune cells known as mast cells and are subsequently neutralized by enzymes, namely histamine N-methyltransferase (HNMT) and diamine oxidase (DAO). Mast cells originate from progenitor cells in the bone marrow, which circulate to several tissues where they mature.

These mature mast cells are known to perform proinflammatory functions and regulate the immune system. They achieve this by releasing mediators like histamine, leukotrienes, cytokines, chemokines, and neutral proteases. In a sense, mast cells act as a battlefront, releasing histamines to defend the body against perceived threats or allergens.

To maintain the body's balance and prevent overreaction, the histamines released by mast cells must be deactivated. This is where the enzymes HNMT and DAO come into play. In particular, DAO is crucial as it helps break down histamines into inactive forms, negating their impact on our systems.

However, individuals with histamine issues often struggle with an insufficient production of DAO, which can exacerbate histamine reactions. DAO is primarily produced in the kidneys, thymus, and the lining of the intestines. Hence, supporting these organs and ensuring adequate DAO production is key to preventing and managing histamine-related issues.


How Histamines are cleared

Moreover, the issue might not solely be due to a lack of the enzyme DAO, which plays a significant role in breaking down histamines. Instead, it could be related to detoxification problems stemming from the liver, kidneys, or gut. These three vital organs are responsible for eliminating toxins and maintaining overall bodily health.

Impaired detoxification processes can adversely affect one's ability to cope with an accumulation of histamines, leading to an increase in allergic reactions or other histamine-related symptoms. Therefore, it is important to maintain the optimal functioning of these organs to promote the efficient removal of toxins, including histamines, and to support overall health and well-being.


Exploring the Cause of Histamine Intolerance

The crucial question arises: Why are you intolerant to histamines? It's not necessarily the consumption of histamine-producing foods that causes your reactions. Instead, it could be that you're either not adequately clearing out histamines, having trouble breaking them down or producing excessive amounts. So, what could be behind these issues?

Various factors can contribute to histamine intolerance, including genetic predispositions, dietary habits, stress levels, and the overall health of the organs involved in breaking down and eliminating histamines, like the kidneys, thymus, and intestinal lining as mentioned before. Identifying the underlying cause of histamine intolerance is essential in managing and preventing allergic reactions, as well as improving overall health and well-being.


Copper Dysregulation

Copper, a vital mineral in human metabolism, plays a significant role as a cofactor for several enzymes that are essential for the overall functioning of the body. One among them is the DAO enzyme, which is responsible for breaking down histamine. Histamine, produced by mast cells, is a compound involved in local immune responses, as well as regulating physiological functions in the gut. Thus, copper contributes to balancing histamine levels in the body, further ensuring a balanced immune response. Bearing this in mind, it's key to understand that a deficiency in copper levels can potentially disrupt this balance. Specifically, copper deficiency is associated with an increase in tryptase, a significant marker of mast cell activation. This augmentation could potentially exacerbate one's histamine reactions within the immune system.

However, the maintenance of optimal copper levels isn't straightforward. Copper, being a highly responsive mineral, requires precise handling within the body to be effectively applied and serve its functions. To delve deeper into the topics of copper deficiency, dysregulation, and toxicity, we invite you to explore our comprehensive article. A closer look at the role that copper plays reveals the importance of a unique protein known as ceruloplasmin. Ceruloplasmin acts as copper's escort, guiding it to the correct tissues and facilitating necessary enzymatic reactions within specific organ systems. Subsequently, this results in the proper synthesis of hormones and biochemical reactions.

Should copper fail to bind to ceruloplasmin properly, unwanted health issues could arise, particularly relating to histamine balance and the body's ability to produce the indispensable DAO enzyme. This elevates copper's role from being a mere mineral to a critical player in the intricate biological processes of the human body.


Histamines, Copper, and Estrogen Dominance

On the flip side, imbalances in copper levels can lead to another intriguing health issue - estrogen dominance, which is characterized by an excessive proliferation of estrogen in the body. The link between copper and estrogen stems from the interpretation of minerals in a hair tissue mineral analysis, where the levels of copper are analogous to the levels of estrogen. Esteemed as the hormone of growth, estrogen is instrumental in the body's production of prostaglandins. These compounds are generated by every cell and are responsible for regulating numerous activities, such as muscle contractions and blood vessel relaxation. The relationship between estrogen and prostaglandins is akin to a double-edged sword. While regular production of prostaglandins is essential, their overproduction can trigger an inflammatory response, potentially inhibiting the DAO enzyme and causing a histamine reaction.

These effects often manifest physically as discomfort – for instance, through cramps that many women encounter. Consequent to its role as the hormone of growth, elevated estrogen levels, or estrogen dominance, can lead to liver congestion. This congestion can act as a barrier to the production of adequate ceruloplasmin, the protein required for binding with copper.

Thus, copper dysregulation can lead to an intricate web of health complications, underlining the importance of maintaining balanced copper levels. A clear understanding of this ties back to the fundamental need to foster a holistic approach to maintaining our health - considering not just individual elements, but also how they interact within the larger biological system.



To address the root problem of copper imbalance, it is essential to focus on promoting the production of ceruloplasmin, which in turn, ensures the effective and efficient use of copper in the body. However, regulating copper is merely one thread in the complex tapestry of metabolic balance that our health depends on. Indeed, a broader perspective would require us to consider other potential influences ranging from mineral imbalances to heavy metal toxicity, nutrient deficiencies, lifestyle factors, and more. In other words, to fully understand and tackle the copper issue, we must adopt a comprehensive view and take into account all other interrelated factors that influence our overall health and well-being.

To aid in this complex task, we recommend undertaking a hair tissue mineral analysis, or HTMA. This analytical test provides extensive data about mineral excess or deficiencies, heavy metal toxicities, and other essential biochemical data. By choosing to conduct an HTMA with us, you can gain an in-depth understanding of your body's mineral profile, guide your nutrition and lifestyle choices, and ultimately, construct a personalized roadmap for achieving optimal health. It's worth remembering that resolving issues regarding copper management or any health-related concern is not just about addressing isolated factors; it's about taking a holistic walk through your health labyrinth, arriving at the core of interconnected issues, and aligning your actions toward comprehensive health empowerment.

Intrigued by the prospect of stepping into a healthier tomorrow? Feel free to click this link to order your personalized hair tissue mineral analysis now, paving your way to resolving those unsettled histamine issues!

Barbara Madimenos
Hair Tissue Mineral Analysis Practitioner
Functional Diagnostic Nutrition Practitioner
Integrative Health Coach

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